Clinicopathological features and outcomes of major. Mucoepidermoid carcinoma mec of the salivary glands represents 5% of all salivary gland tumors and 20% of the malignant forms. Mucoepidermoid carcinoma of the salivary glands has been described. Epithelial mucin muc status may aid in establishing a more accurate grade. Immunohistochemical expression profiles of mucin antigens. The current study investigated the usefulness of these features in determining the prognoses of patients with mucoepidermoid carcinomas of the major salivary glands.
This malignancy originates in both major and minor salivary glands, although it generally occurs in the parotid gland 89. The parotid glands, the largest salivary glands, are just in front of the ears. These tumours account for 5% of all salivary gland tumours commonly arise within the parotid gland and are the most common malignant tumour to arise in children and adults under 20 years of age. It is critical to predict which mec patients are prone to develop recurrencemetastases. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in. Sclerosing mucoepidermoid carcinoma of the salivary glands. Epithelial neoplasms originating in the minor salivary glands account for approximately 15% of all salivary gland neoplasms 6, 38. Full text evaluation of salivary gland lesions by fine. Pa pleomorphic adenoma, mec mucoepidermoid carcinoma, scc. The aim of this study is to present the casuistic of mucoepidermoid carcinoma of salivary glands in patients diagnosed at dr. For accreditation purposes, this protocol should be used for the following procedures and tumor types. Salivary gland tumours comprise almost 5% of head and neck malignancies. Mucoepidermoid carcinoma mec, one of the most common salivary gland malignancies, is rare in children. Mucoepidermoid carcinoma is thought to arise from pluripotent reserve cells of the excretory ducts of salivary gland that have the potential to differentiate into squamous, columnar and mucous cells.
Role of radiotherapy for mucoepidermoid carcinoma of salivary. Mucoepidermoid carcinoma of oral mucosa bmj case reports. Evaluation and application of grading criteria in 143 cases. Setting kaiser permanente southern california medical group from 1993 to 2016. Mucoepidermoid carcinoma genetic and rare diseases.
The reason has been suggested to be the difficulty of obtaining a sufficiently wide surgical margin for minor salivary gland tumors. This study aimed to investigate the expression of various mucins muc1, muc2, muc4 and muc5ac in mecs. A 64yearold male was diagnosed with hmec based on malignant squamous cells and mucussecreting cells in immunohistochemical examination. Sep 11, 2009 mucoepidermoid carcinoma, representing 5% of all salivary gland tumors and 20% of the malignant forms, is the most frequent primary malignancy of the salivary gland in both adults and children. Ultrastructural study of the histogenesis of salivary gland. Mucoepidermoid tumour, salivary gland neoplasms, minor salivary gland introduction. Methods a 64yearold male was diagnosed with hmec based on malignant squamous cells and mucussecreting cells in. The most common ones adenoid cystic, mucoepidermoid lowgrade, acinic cell. Introductionin 1945, stewart et al 1 recognized mucoepidermoid of the salivary gland as a separate entity among salivary neoplasm. The current study investigated the usefulness of these features in determining the prognoses of patients with mucoepidermoid carcinomas of the major salivary. The age of the patients ranged between 7 and 84 years.
Prognostic factors in mucoepidermoid carcinoma of the minor. The tumors of the salivary glands are uncommon head and neck neoplasms. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland. Healey wv, perzin kh, smith l 1970 mucoepidermoid carcinoma of salivary gland origin. Pdf salivary gland tumours are a relatively rare and. There are many types of benign salivary gland tumors, with names such as adenomas. However, in the pediatric patient population, 50% of parotid gland tumors are malignant, but only 10% of submandibular gland tumors do. Pleomorphic adenoma pa, the most common salivary gland tumor, accounts for 54. Mucoepidermoid carcinoma of the major salivary glands. The majority of cases occurring in the 4th and 5th decades of life and they are histologically lowgrade malignant neoplasm usually affecting the mandible. Mucoepidermoid carcinoma of the major salivary glands goode. Background primary hepatic mucoepidermoid carcinoma hmec is extremely rare and the molecular etiology is still unknown.
A mucoepidermoid carcinoma is a tumour that usually occurs in the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. As our knowledge base has evolved, it is clear that carcinoma ex pleomorphic adenoma is not automatically a high grade tumor as is traditionally suggested. Contribution to the development of tumours in salivary gland cysts. Pdf central mucoepidermoid carcinoma of mandible a. Mucoepidermoid carcinoma of the parotid gland in children. In 1991 the world health organization who suggested that the term mucoepidermoid tumor should be changed to mucoepidermoid carcinoma. Lepp first reported an intraosseous mucoepidermod carcinoma mec of the mandible in 1931 1. About 75%80% of these tumors are benign and include. Although the parotid gland is the most common site of involvement. Further, authors found that the parotid gland was the. Diagnostic and prognostic utility of 18ffdg petct in. Pdf mucoepidermoid carcinoma of the salivary glands.
Protocol for the examination of specimens from patients with carcinomas of the major salivary glands. Highgrade mucoepidermoid carcinoma of the mandibular. Clinical data and 15 histopathologic features were compared in 4 patient groups based on outcome after initial treatment. A total of 146 patients with recurrent salivary gland cancer were treated at our institution between january 2002 and december 2015. Mucoepidermoid carcinoma in a salivary duct cyst of the.
Ultrastructural study of the histogenesis of salivary. Central mucoepidermoid carcinoma cmc is an uncommon tumor, comprising 23 % of all mucoepidermoid carcinomas reported. Prognostic factors in mucoepidermoid carcinoma of the. The 2 main types of salivary glands are the major salivary glands and minor salivary glands. Sclerosing mucoepidermoid carcinoma with eosinophilia of the. The authors had previously conducted an investigation of minor salivary gland mucoepidermoid carcinoma, in which they demonstrated that certain clinical and histopathologic features were useful in predicting biologic outcome. Introductionmucoepidermoid carcinoma mec is a common malignant salivary gland neoplasm presumed to arise from the reserve cells of salivary gland ducts. The findings of the present case suggest that this rare type of salivary gland carcinoma may be associated with a chronic inflammatory condition such as igg4. Benign salivary gland tumors most salivary gland tumors are benign that is, they are not cancer and will not spread to other parts of the body. However, the sheer variety of tumor type and the rarity of these tumors pose challenges to devising highly predictive grading schemes. Mec constitutes 310% of all tumours of major salivary glands and 1015% of tumours of minor salivary glands. Mucoepidermoid carcinoma mec is the most common 29 to 35% malignant neoplasm of the major and minor salivary glands in both adults and children. Mucoepidermoid carcinoma of salivary glands practiceupdate. June 2017 includes ptnm requirements from the 8th edition, ajcc staging manual.
Mucoepidermoid carcinoma mec has an annual incidence of 0. Diseasespecific and recurrencefree survival were stratified by tumor grade. We report the case of a 72yearold malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid carcinoma of the soft palate. Mucoepidermoid carcinoma mec is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor mucoepidermoid carcinoma of minor salivary glands. Mucoepidermoid carcinoma of the soft palate salivary gland. So, consistent with the above criteria, the tumor was classified as a highgrade mucoepidermoid carcinoma. Minor salivary gland mucoepidermoid carcinoma in children. Mucoepidermoid carcinoma generally affects the salivary glands and only rarely is located in the jaws 11,12. Mucoepidermoid carcinoma of buccal mucosa bmj case reports. Mucoepidermoid carcinoma mec is the most common malignant salivary gland tumor. Sep 21, 2020 mucoepidermoid carcinoma mec is the most common malignant salivary gland tumour in both adults and children.
The crtc1maml2 fusion gene was previously detected in a primary hmec, which is often associated with mec of salivary gland in the literature. The case presented is a 41 year old woman with central mucoepidermoid carcinoma at the left posterior of the. Primary hepatic mucoepidermoid carcinoma hmec is extremely rare and the molecular etiology is still unknown. Sep 28, 2017 the 2 main types of salivary glands are the major salivary glands and minor salivary glands. Immunohistochemical expression profiles of mucin antigens in. Mucoepidermoid carcinoma mec is considered the most common malignant salivary gland tumour. The proper diagnosis of salivary glands neoplasms is complex, and the otorhinolaryngologisthead and neck surgeon needs to. Histocytologic grading of mucoepidermoid carcinoma of major. Low, intermediate, and highgrade neoplasms accounted for 61. Synchronous multiple unilateral parotid gland tumors of benign and malignant histological types. Among malignant tumors, mucoepidermoid carcinoma was the most common.
Mucoepidermoid carcinoma an overview sciencedirect topics. Apr 15, 1992 mucoepidermoid carcinoma of intraoral salivary glands. Oct 31, 2000 mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands. There is also an increased risk for carcinoma of other organ systems following a primary benign or malignant salivary gland neoplasm, including breast, thyroid, bronchus and ovary 1,4,17, although some of. The tumour is a firm to hard mass and is usually asymptomatic. Histological grading of mec is subjective, but plays an important role in predicting patient prognosis. In mucoepidermoid carcinoma mec, the most common salivary gland carcinoma, there is a lack of novel prognostic markers, but postoperative early recurrence strongly affects the clinical course and a poor outcome. Mucoepidermoid carcinoma mec is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma tumors consist of both mucinous and epidermoid cells, although several additional cell types are also found. Stewart fw, foote fw, becker wf 1925 mucoepidermoid tumors of salivary glands.
Dec 16, 2011 of these, mucoepidermoid carcinoma mec is the most common, representing 30% to 40% of all salivary gland malignancies 1 and up to 50% of parotid malignancies. P63 immunohistochemical expression pattern can be helpful in distinguishing lowgrade mucoepidermoid carcinoma from papillary cystadenoma of the salivary glands. Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. The most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It has been estimated that about 1% to 5% of all salivary gland tumors develop in children and adolescents 1, 8, and mec is the most common malignancy 5, 9, 39, 40.
Sep 28, 2017 minor salivary glands most often start in the roof of the mouth. Mucoepidermoid carcinoma was most common in the parotid gland 44. A case of metastatic mucoepidermoid carcinoma complicated. There are 3 sets of major salivary glands on each side of the face.
Mucoepidermoid carcinoma mec is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor. The second most common minor salivary gland tumour 1240% globally is mucoepidermoid carcinoma. Tumors of salivary glands are uncommon and comprise of about 2%4% of all head and neck tumors. Approximately 80% of salivary gland tumors are considered benign, pleomorphic adenoma being the most common type. Mucoepidermoid carcinoma was the most common malignant salivary gland tumor. Only 23 cases of sclerosing mucoepidermoid carcinoma with or without eosinophilic infiltratie have been reported to date in such an anatomical location. Mucoepidermoid carcinoma mec comprises approximately 1015% of all salivary gland neoplasms and about 30% of salivary malignancies.
Pleomorphic adenoma was the most common of the benign tumors, and mucoepidermoid carcinoma was the most frequent malignant tumor. Mucoepidermoid carcinoma what is, treatment, survival rate. Pdf mucoepidermoid carcinoma is a malignant epithelial tumour of glandular tissue, usually of the major salivary glands. It is composed of varying proportions of mucous, epidermoid, intermediate, and clear cells, and often demonstrates prominent cystic pattern 1, 3. Mucoepidermoid carcinoma mec is one of the most commonly occurring malignant salivary gland neoplasm, and contributes 2.
Clinicopathological significance of the crtc3maml2 fusion. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in the parotid gland. Jan 01, 1999 poorer prognosis for minor salivary glands than for major salivary glands has been reported for adenoid cystic carcinoma of salivary gland4, 5, 6, 24. Prognostic significance of p27 and ki67 expression in. Lowgrade mucoepidermoid carcinoma of salivary glands. Mucoepidermoid carcinoma in a salivary duct cyst of the parotid gland. Mucoepidermoid carcinoma of the salivary glands springerlink. Dec 01, 2007 mucoepidermoid carcinoma accounts for up to 16% of all salivary glands tumors and approximately 30% of salivary gland malignancies. From january 2002 to december 2012, 51 cases were diagnosed as mucoepidermoid carcinoma. About 7 out of 10 salivary gland tumors start here. Download citation sclerosing mucoepidermoid carcinoma of the salivary glands.
In human pathology, salivary gland neoplasms represent less than 0. In salivary gland tumours with dual ductal cellmyoepithelial cell differentiation such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma. A study of mect1maml2 in mucoepidermoid carcinoma and. Mucoepidermoid carcinoma mec is the most common malignant salivary gland neoplasm, representing 10 to 15% of all salivary neoplasms. Mucoepidermoid carcinomas are the most common type of salivary gland cancer and most often appear in the parotid. Most tumors of the minor salivary glands are malignant. The patient is on regular followup and is disease free after 3 years.
Mec mainly occurs in the parotid gland, along with minor glands being the second common. We investigated the diagnostic and prognostic utility of pet in this setting. Eduardo caceres graziani national institute for neoplastic diseases, lima, peru. Wholeexome sequencing reveals the etiology of the rare. Salivary gland tumors constitute a highly heterogeneous histopathologic group. There are three pairs of major sgs parotid, submandibular, and sublingual glands and in the submucosa of the oral cavity occur many minor salivary glands. Cords, sheets and clusters of mucous, squamous, intermediate and clear cells. The present series includes 39 cases of mucoepider mucoepidermoid carcinomas are composed by three moid carcinoma of salivary gland origin, primarily cell types in variable amounts. Mucoepidermoid carcinoma presented increased immunoexpression of p63 compared with the other groups. The ten cases of parotid origin in this report formed 5 per cent of tumors of this gland.
Discussion primary central salivary gland carcinomas of the mandible are uncommon neoplasms 10. Dec 01, 2020 mucoepidermoid carcinoma mec is the most common malignant salivary gland neoplasm, representing 10 to 15% of all salivary neoplasms. Expression of mucins in salivary gland mucoepidermoid carcinoma. This electronmicroscope study of the histogenesis of mucoepidermoid carcinoma is based on 15 cases from the major and minor salivary glands. The purpose of this study was to evaluate the clinical outcomes of mec of minor salivary glands in a group of 16 patients, who were treated in our.
The role of 18 ffdg petct in the evaluation of recurrent salivary gland tumors remains poorly defined. Classification clinicalpathologic correlation, and results of treatment. Pdf mucoepidermoid carcinoma of the soft palate salivary gland. Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Feb 25, 2009 histologic grade is a significant predictor of outcome in salivary gland carcinomas. The frequency of malign lesions varies from site to site and are seen in 15% in the parotid and in 40% in the submandibular gland.
However it can present in the minor salivary glands, especially in the soft palate. P63 expression in papillary cystadenoma and mucoepidermoid. Minor salivary gland mucoepidermoid carcinoma in children and. Pdf mucoepidermoid carcinoma of the tongue base mimicking. Mucoepidermoid and adenoid cystic carcinomas of the esophagus. This prospective multicenter study included 292 patients with mucoepidermoid carcinoma, the most common histology of salivary gland tumors, with the purpose of providing clinical and prognostic descriptions of salivary gland tumors in europe.
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